A Pharmacoeconomic Model to Evaluate Antibiotic Costs

摘要: Study Objectives. To characterize patient sociodemographics and health, describe vancomycin treatment parameters clinician-rated outcomes, determine costs associated with including preparation administration, adverse events, toxicity. Design. A prospective study to develop a model for antibiotic (vancomycin). Setting. community hospital. Patients. One hundred adults active infections. Interventions. Mean duration of therapy was 10 days, most patients received 2000 mg/day. Serum concentrations were monitored in two three patients. Detailed cost analyses completed on subset 26 selected at random from the overall sample. Measurements Main Results. Sepsis skin structure infections common indications therapy. Treatment effective 81 patients, failed 9, not evaluable 10. Thirty-eight percent experienced events attributable drug. Phlebitis common, red man syndrome, nephrotoxicity, ototoxicity infrequent. Conclusions. Total 100 $30,251: $23,855 $1710 monitoring serum concentrations, $4686 treating reactions. Drug accounted only 55% total cost. Vancomycin is safe effective, but phlebitis underreported significantly affects