Mechanisms of drugs that affect uterine motility.

摘要: Modern obstetrics relies on a collection of drugs that affect the motility uterus either to stimulate or suppress uterine contractions. Although comprehensive, detailed understanding how these work does not yet exist, many, such as oxytocin, appear by altering cytosolic calcium levels in smooth muscle cells. Other drugs, ritodrine, only alter levels, but seem inactivate myosin light chain kinase, critical enzyme necessary for initiation This report is intended summarize current state knowledge regarding uterus. The delineation molecular mechanisms action important because it provides basis their rational therapeutic use well design new and better uterotrophic drugs.