Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock

摘要: Mammalian physiology resonates with the daily changes in external environment, allowing processes such as rest-activity cycles, metabolism, and body temperature to synchronize surroundings. Studies have identified molecular underpinnings of robust oscillations gene expression occurring over 24-h day, but how acute or chronic perturbations modulate rhythms, physiology, behavior is still relatively unknown. In this issue Genes & Development, Hong colleagues (pp. 1367-1379) studied inflammation interacts circadian clock. They found that NF-κB signaling can modify chromatin states genes core clock network well locomotor behavior. Interestingly, a high-fat diet (HFD) fed mice also triggers pathway, suggesting cross-regulatory circuits link inflammation, HFD,