Pharmacokinetic study of caffeic and rosmarinic acids in rats after oral administration.

摘要: p-Coumaric and ferulic acid are actively taken up by monocarboxylic transporter (MCT), whereas gallic acid, caffeic (CA), rosmarinic (RA) absorbed paracellular diffusion in human intestinal Caco-2 cells, although CA has low affinity for MCT. We previously demonstrated that p-coumaric a much higher absorption efficiency than rats, owing to the MCT-mediated of vivo (J. Agric. Food Chem. 2004, 52, 2527-2532). Here, orally administered RA rats been studied investigate their characteristics pharmacokinetics compare results with those acids obtained under identical conditions. Rats were given 100 micromol/kg body weight RA, blood was collected from portal vein abdominal artery after administration. CA, metabolites quantified coulometric detection method using HPLC-ECD. The serum concentration intact peaked at 10 min administration, C(max) 11.24 micromol/L 1.36 RA. area curve (AUC) calculated concentration-time profile be 585.0 60.4 micromol L-1, respectively. about 9.7-fold Overall, these compounds increases order: = < which is good agreement cells vitro.