Reciprocal regulation of NO signaling and TXNIP expression in humans: Impact of aging and ramipril therapy☆

摘要: Abstract Background Impaired tissue responsiveness to nitric oxide (NO) occurs in many cardiovascular diseases as well with advanced age and is a correlate of poor outcomes. This phenomenon results from oxidative stress, NO "scavenging" dysfunction soluble guanylate cyclase (sGC). Thioredoxin-interacting protein (TXNIP) major intracellular regulator inflammatory activation redox but its interactions NO/sGC are poorly understood. We have now evaluated the relationship between platelet TXNIP expression function axis subjects varying during therapy ramipril. Methods & Young (n=42) aging (n=49) underwent evaluation content. Aging additionally had measurements routine biochemistry. Platelet content was greater (376±33units) compared younger (289±13units; p Conclusions increases aging, varies inversely NO, diminishes rapidly following treatment These data suggest that TXNIP-induced stress may be critical modulator resistance fundamental basis for disease. Analogously suppression can potentially utilized an index restoration homeostasis.