miR-632 promotes gastric cancer progression by accelerating angiogenesis in a TFF1-dependent manner

作者: Ying Shi , Xiaoxiao Huang , Guobin Chen , Ying Wang , Yuansheng Liu

DOI: 10.1186/S12885-018-5247-Z

关键词:

摘要: Gastric cancer (GC) is a common malignant disease worldwide. Aberrant miRNAs expression contributes to cells behaviour, and in preclinical research, miRNA targeting has shown potential for improving GC therapy. Our present study demonstrated that miR-632 promotes progression trefoil factor 1 (TFF1)-dependent manner. We collected tissues serum samples detect using real-time PCR. A dual-luciferase reporter assay was used identify whether directly regulates TFF1 expression. Tube formation endothelial cell recruitment assays were performed with or without treatment. Western blot situ hybridization angiogenesis markers are affected by miR-632. results showed highly expressed tissue negatively associated GC. improves tube regulating cells. Recombinant reversed miR-632-mediated angiogenesis. target gene of accelerating TFF1-dependent Targeting may be therapeutic approach patients.

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