Secretion patterns of brain natriuretic peptide and atrial natriuretic peptide in patients with or without pulmonary hypertension complicating atrial septal defect

摘要: Abstract Background This study was designed to investigate plasma levels of atrial natriuretic peptide (ANP) and brain (BNP) in patients with septal defect (ASD), whose right ventricular loading patterns vary from simple volume overloading both pressure overloading. Methods Results Plasma ANP BNP the pulmonary artery were measured 31 adult ASD 11 control subjects. On basis presence hypertension (PH, mean arterial >20 mm Hg), divided into two groups, without PH (group 1, n = 21) those 2, 10). Cardiac catheterization performed measure blood flow. significantly higher group 1 2 than group. (BNP/ANP) ratio group, although they not elevated 1. positively correlated degree flow ( r 0.54, p 0.73, a powerful marker for (sensitivity 90%, specificity 90%). Conclusions regardless PH. In contrast, proportion severity complicating ASD. Thus may represent differing aspects cardiac response overload (Am Heart J 1998;136:297-301.)