p16 expression as a surrogate marker for HPV‐related oropharyngeal carcinoma: A guide for interpretative relevance and consistency

摘要: Recent studies of oropharyngeal carcinoma have reported remarkable correlation between integrated human papillomavirus (HPV) viral detection and p16 protein overexpression in tumor cells. These findings led to calls for the substitution expression more demanding HPV testing clinical practice. The rationale such practice is largely driven by simplicity, low cost, feasibility immunohistochemical (IHC) analysis. There are, however, several caveats that need be fully considered. include subjective nature IHC evaluation, variable mechanisms head neck squamous cell carcinoma, lack scoring interpretive criteria. This perspective addresses conceptual practical issues associated with analysis provides a broad outline its application evaluation patients carcinoma.