The role of the NLRP3 Inflammasome in the pathogenesis of airway disease

摘要: The incidences of respiratory diseases like asthma and Chronic Obstructive Pulmonary Disease (COPD) are increasing dramatically. Significantly, there currently no treatments that can slow or prevent the relentless progression COPD; a sub-population asthmatics resistant to available therapies. What is more, prescribed medication has only minimal effect on symptoms suffered in these patient groups. There therefore an urgent need develop effective drugs treat diseases. Whilst COPD thought be distinct diseases, it believed pathogenesis both driven by chronic inflammation present airways patients. It thus hypothesised if could attenuated, disease development would slowed reduced. paramount determine pathways driving/propagating inflammation. Recently been growing body evidence suggest multimeric protein complex known as Inflammasome may play key roles observed aim this review discuss role NLRP3 Inflammasome, its associated inflammatory mediators (IL-1β IL-18), COPD.