Treatment of the Newly Diagnosed Adult with De Noyo Acute Myeloid Leukemia

作者: Richard M. Stone , Robert J. Mayer

DOI: 10.1016/S0889-8588(18)30257-0

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摘要: Recent studies suggest that the administration of intensive postremission therapy, which includes high-dose cytarabine, results in a longer period disease-free survival when compared with lower dose treatment. In view these improved results, it is uncertain currently whether younger patients acute myeloid leukemia (AML) first remission should be offered such chemotherapy or either allogeneic autologous bone marrow transplantation. Currently ongoing clinical trials, laboratory-based prognostic factor analysis, and attempts at better underStanding pathophysiology may provide more precise guidelines for choosing best treatment among alternatives any given individual AML remission.

参考文章(84)
Capizzi Rl, Capizzi Rl, Richards F nd, Richards F nd, Cooper Mr, Spurr Cl, Spurr Cl, White Dr, White Dr, Jackson Dv, Jackson Dv, Poole M, Poole M, Muss Hb, Muss Hb, Stuart Jj, Stuart Jj, Hopkins Jo, Hopkins Jo, Treatment of poor risk acute leukemia with sequential high-dose ARA-C and asparaginase Blood. ,vol. 63, pp. 694- 700 ,(1984) , 10.1182/BLOOD.V63.3.694.694
RO Dillman, RB Davis, MR Green, RB Weiss, AJ Gottlieb, S Caplan, S Kopel, H Preisler, OR McIntyre, C Schiffer, A comparative study of two different doses of cytarabine for acute myeloid leukemia: a phase III trial of Cancer and Leukemia Group B. Blood. ,vol. 78, pp. 2520- 2526 ,(1991) , 10.1182/BLOOD.V78.10.2520.2520
FR Appelbaum, RA Clift, CD Buckner, P Stewart, R Storb, KM Sullivan, ED Thomas, Allogeneic marrow transplantation for acute nonlymphoblastic leukemia after first relapse Blood. ,vol. 61, pp. 949- 953 ,(1983) , 10.1182/BLOOD.V61.5.949.949
M. Labopin, B. Lowenberg, G. Meloni, P. Colombat, A. Carella, B. Simonsson, I. M. Franklin, A. Burnett, E. P. Alessandrino, N. C. Gorin, R. Willemze, V. Rizzoli, P. Coser, A. Ferrant, S. Brunet Mauri, W. Helbig, E. Polli, G. Souillet, P. Herve, M. Korbling, A. Iriondo, B. Bjorkstrand, L. F. Verdonck, Autologous bone marrow transplantation for acute myeloblastic leukemia in Europe : further evidence of the role of marrow purging by mafosfamide Leukemia. ,vol. 5, pp. 896- 904 ,(1991)
KR Rai, JF Holland, OJ Glidewell, V Weinberg, K Brunner, JP Obrecht, HD Preisler, IW Nawabi, D Prager, RW Carey, MR Cooper, F Haurani, JL Hutchison, RT Silver, G Falkson, P Wiernik, HC Hoagland, CD Bloomfield, GW James, A Gottlieb, SV Ramanan, J Blom, NI Nissen, A Bank, RR Ellison, F Kung, P Henry, OR McIntyre, SK Kaan, Treatment of acute myelocytic leukemia: a study by cancer and leukemia group B. Blood. ,vol. 58, pp. 1203- 1212 ,(1981) , 10.1182/BLOOD.V58.6.1203.BLOODJOURNAL5861203
ED Ball, LE Mills, R McMillan, CT Coughlin, BH Davis, GG d Cornwell, TA Stukel, AL Howell, W Spruce, BJ Dain, Autologous bone marrow transplantation for acute myeloid leukemia using monoclonal antibody-purged bone marrow Blood. ,vol. 75, pp. 1199- 1206 ,(1990) , 10.1182/BLOOD.V75.5.1199.1199
PA Cassileth, CB Begg, JM Bennett, M Bozdech, SB Kahn, C Weiler, JH Glick, A randomized study of the efficacy of consolidation therapy in adult acute nonlymphocytic leukemia. Blood. ,vol. 63, pp. 843- 847 ,(1984) , 10.1182/BLOOD.V63.4.843.843