Drug streaming during intra-arterial chemotherapy.

摘要: ✓ Treatment of brain tumors by intra-arterial (IA) chemotherapy is occasionally complicated sites focal toxicity in the and retina. A possible cause non-uniform drug delivery due to intravascular streaming. To investigate this phenomenon vivo, authors examined distribution after internal carotid artery (ICA) infusion rhesus monkeys. Carbon-14 (14C)-labeled iodoantipyrine was delivered into ICA eight monkeys at slow rates (1% 2% flow) or fast (20% combined with additional techniques promote mixing blood. Two received intravenous (IV) 14C-antipyrine. Uniformity assessed comparing high-to-low ratios isotope concentration four regions evaluated quantitative autoradiography. There striking non-uniformity IA group, as much 13-fold differences anatomically conti...