Antimycobacterial Agents: To Target or Not to Target

摘要: Mycobacterium tuberculosis, leprae, and ulcerans are the three most common pathogens of mycobacterium genus. M. causative agent tuberculosis in humans, is dangerous bacterial pathogen. In fact as per latest WHO report, killed more people than HIV last few years now leading cause death. The worst affected from global TB epidemic nine high-burden countries which includes China India. 23% total cases reported India, indicating that serious efforts needed to tackle incidence, prevalence, mortality. Another concern rise multiple drug-resistant strains all current antimycobacterial agents will no longer be effective future. Research drug discovery remains abysmal there shortfall USD 1.6 billion treat neglected disease. does not attract major funding developed prioritize cancer, HIV, malaria. As getting costlier, pharmaceutical companies do find research financially viable. This has resulted gap between pipeline need for new drugs. challenge stop by finding effectively MDR-TB XDR-TB months years. chapter describe agents, their mechanisms, candidate molecules clinical trials. goal understand how old drugs worked we can design strategies develop agents.