Combination of Multiple Molecular Markers Can Improve Prognostication in Patients With Locally Advanced and Lymph Node Positive Bladder Cancer

摘要: Purpose: We tested whether the combination of 4 established cell cycle regulators (p53, pRB, p21 and p27) could improve ability to predict clinical outcomes in a large multi-institutional collaboration patients with pT3-4N0 or pTany Npositive urothelial carcinoma bladder. also assessed molecular markers is superior any individual biomarker.Materials Methods: The study comprised 692 bladder treated radical cystectomy bilateral lymphadenectomy (median followup 5.3 years). Scoring was performed using advanced imaging color detection software. base model incorporated patient age, gender, stage, grade, lymphovascular invasion, number lymph nodes removed, positive nodes, concomitant situ adjuvant chemotherapy.Results: Individual did not predictive accuracy for disease recurrence cancer specific mortalit...