Topical and systemic medications for the treatment of primary Sjögren's syndrome

摘要: The treatment of primary Sjogren's syndrome (SS) is based principally on the management sicca features and systemic manifestations. Sicca manifestations are treated symptomatically through administration topical therapies, such as saliva substitutes artificial tears; in patients with residual salivary gland function, stimulation flow a sialogogue therapy choice. extraglandular must be tailored to specific organ or organs involved; however, limited data have been obtained from controlled trials SS guide symptoms using therapies including antimalarials, glucocorticoids, immunosuppressive drugs biologic agents. Nevertheless, randomised agents that target molecules receptors involved aetiopathogenesis initiated new era therapeutic disease, although potential risks benefits these carefully considered. In this Review, we analyse evidence regarding efficacy currently available treat SS. On basis evidence, provide guidance use different clinical scenarios.