Mutagenicity and human chromosomal effect of stevioside, a sweetener from Stevia rebaudiana Bertoni.

摘要: Leaves of Stevia rebaudiana Bertoni have been popularly used as a sweetener in foods and beverages for diabetics obese people due to their potent stevioside. In this report, stevioside steviol were tested mutagenicity Salmonella typhimurium strains TA98 TA100 chromosomal effects on cultured human lymphocytes. Stevioside was not mutagenic at concentrations up 25 mg/plate, but showed direct only 50 mg/plate. However, did exhibit either or TA100, with without metabolic activation. No significant effect observed blood lymphocytes from healthy donors (n = 5). This study indicates that are neither nor clastogenic vitro the limited doses; however, vivo genotoxic tests long-term yet be investigated.