An Efficient Synthesis of β-C-Glycosides Based on the Conformational Restriction Strategy: Lewis Acid Promoted Silane Reduction of the Anomeric Position with Complete Stereoselectivity
作者： Masaru Terauchi , Hiroshi Abe , Akira Matsuda , Satoshi Shuto
DOI: 10.1021/OL048525+
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摘要: The reduction of glyconolactols having an anomeric carbon substituent by Et3SiH/TMSOTf proceeded with complete stereoselectivity to produce the corresponding β-C-glycosides when substrates were conformationally restricted in 4C1-chair form a 3,4-O-cyclic diketal or 4,6-O-benzylidene protecting group. Thus, efficient construction was achieved on basis conformation restriction strategy.
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