Laser-photobiomodulation on experimental cancer pain model in Walker Tumor-256

摘要: Abstract Context Cancer Pain is considered a common and significant clinical problem in malignant neoplasms, comprising 20% to 50% of all patients with tumor progression. Laser photobiomodulation (L-PBM) has been used multitude pain events, ranging from acute trauma chronic articular. However, L-PBM never tested cancer pain. Objectives Evaluate hyperalgesia, edema, COX-1, COX-2, IL-10, Bdkrb1 mRNA low-level laser irradiated Walker-256 tumor-bearing rats. Methods Rat hind paw injected Walker Tumor-256 (W-256) divided into six groups 6 rats: G1 (control) - W-256 injected, G2- W-256 + Nimesulide, G3- W-256 + 1 J, G4- W-256 + 3 Jand G5- W256 + 6 J. parameters: λ = 660 nm, 3.57 W/cm2, O = 0.028 cm2. Mechanical hyperalgesia was evaluated by Randall–Selitto test. Plethysmography measured edema; levels Bdkrb1were analyzed. Results It found that the W-256 + 1 J group showed decrease reduction threshold. Higher IL-10 lower COX-2 were observed. Conclusion suggest 1 J L-PBM reduced expression increasing gene expression, promoting analgesia close nimesulide.