Geographic variation in human mitochondrial DNA control region sequence: the population history of Turkey and its relationship to the European populations.

摘要: The hypervariable segment I of the control region mtDNA (positions 16024-16383) was amplified from hair roots by PCR and sequenced in 45 unrelated individuals Anatolia (Asian Turkey). Forty different sequences were found, defined 56 variable positions, which only one involves a transversion. neighbor-joining tree Kimura's distance matrix for all shows four main clusters. Cluster D found to be most statistically robust four, it shared mutation that is present European West Asian populations. variability cluster could have originated between 37,000 107,000 years ago. No branch unexpectedly long, denoting absence diverged much before others. pairwise difference distribution bell-shaped, accordance with population expansion occurring roughly 35,000 100,000 When compared other Caucasoid populations through distribution, there pattern Middle East (older expansion) various populations, Turkey an intermediate position; when Turkish are on genetic this position again evidenced. Although very low level divergence among as shown sequences, geographic variation emerges, stepping-stone Europe, agreement hypothesis replacement Neanderthals modern humans, related Upper Paleolithic cultural expansion.