Reversal of excessive effect of regular anticoagulation: low oral dose of phytonadione (vitamin K1) compared with warfarin discontinuation.

摘要: To determine the best way to reverse excessive effect of regular anticoagulation in patients with INR > 5 and no bleeding complications, 23 were randomly subdivided into two groups: group A (n = 12) discontinued warfarin for one day B 11) received 2 mg vitamin K1 orally addition usual dose. was determined after 24 h (day 1), which both groups continued their dose warfarin. After 48 2), dosage changed according value. On 9, values again. Five out twelve had on 1. One patient an value < days 1 2. All eleven 1, all but acceptable (INR 2.0-4.5) ten eight patients. These findings suggest that a low oral is convenient treatment complications.