Plasticity-related serine proteases in the brain (review).

摘要: Serine proteases exert a variety of functions in the body; food digestion, regulation other proteins and modification extracellular matrix. Cumulative evidence has shown importance serine nervous system as well. It been that three proteases, thrombin, plasminogen activators neuropsin, have functional roles neural plasticity. Most actions thrombin are thought to be mediated by its specific receptors. Thrombin reverses neurite outgrowth serum-deprived neuroblastoma cells, induces protective apoptotic effects on neurons glial cells depending concentration time. Tissue-type urokinase-type (tPA uPA) distribute broadly brain. tPA uPA during development. These also function long-term potentiation kindling formation. Furthermore, is essential excitotoxic neuronal cell death. Neuropsin protease expressed limbic Kindling induced neuropsin mRNA protein expression anti-neuropsin antibody ameliorates epilepsy. The possible these plasticity reviewed here.