Bim's Effect on the Expression of miR-423-3p in Promoting Primary Hepatic Cancer (PHC) and Role of miR-423-3p in PHC Proliferation and Invasion.
作者： Zhiqiang Liu , Yunfu Cui
DOI: 10.1007/S10528-021-10052-Z
关键词:
摘要: In this study, we analyzed the miR-423-3p expression in primary hepatic cancer (PHC), its effect on cell proliferation, and migration explored Bcl-2-interacting mediator role of promoting liver cancer. The levels LC tissues adjacent non-tumor were compared, relationship between clinical pathological characteristics patients was analyzed. These peripheral blood healthy volunteers diagnostic value BCL-2-interacting mediators death (Bim) cells SMMC-7721 Huh-7 changes invasion, apoptosis level evaluated. Furthermore, association regulatory Bim evaluated by dual luciferase report. increased, indicating could be a marker for LC. relatively low with TNM stage (I–II) serum AFP level ≤ 20 μg/L, related to 5-year survival rate patients. dramatically higher than that those high expression. can promote proliferation inhibit apoptosis, their growth metastasis, also regulate increased invasion apoptosis.
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