Perinatal Outcome of Children Born to Mothers with Thyroid Dysfunction or Antibodies: A Prospective Population-Based Cohort Study
作者： Tuija Männistö , Marja Vääräsmäki , Anneli Pouta , Anna-Liisa Hartikainen , Aimo Ruokonen
DOI: 10.1210/JC.2008-1520
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摘要: Context: There are only a few large prospective studies involving evaluation of the effect maternal thyroid dysfunction on offspring and observations inconsistent. Objective: The objective study was to investigate effects or antibody positivity perinatal outcome. Setting Participants: included population-based Northern Finland Birth Cohort 1986 including 9247 singleton pregnancies. First-trimester serum samples were analyzed for hormones [TSH, free T4 (fT4)] antibodies [thyroid-peroxidase (TPO-Ab) thyroglobulin (TG-Ab)]. Mothers classified by their hormone status into percentile categories based laboratory data compared accordingly. Main Outcomes: Outcomes mortality, preterm delivery, absolute gestational age-adjusted birth weight, relative placental weight. Results: TPO-Ab- TG-Ab-positive mothers had higher perin...
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