Antiproliferative effect of sulindac in colonic neoplasia prevention: role of COOH-terminal Src kinase.
作者： Dhananjay P. Kunte , Ramesh K. Wali , Jennifer L. Koetsier , Hemant K. Roy
DOI: 10.1158/1535-7163.MCT-08-0022
关键词:
摘要: Although the nonsteroidal anti-inflammatory drugs (NSAID) protection against colorectal cancer is well established, molecular mechanisms remain unclear. We show herein that induction of tumor suppressor gene COOH-terminal Src kinase (Csk) by NSAID important for their antiproliferative and hence chemopreventive effects. In azoxymethane-treated rat model experimental colon carcinogenesis, sulindac treatment markedly induced Csk with a corresponding increase in inhibitory phosphorylation (Tyr527). Sulindac-mediated was replicated human cell line HT-29, suppression both activity (63% vehicle; P
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