Radiosensitization of C6 glioma by thymidine and 41.8°C hyperthermia
作者： Justin D. Cohen , H. Ian Robins , Manucher J. Javid
DOI: 10.3171/JNS.1990.72.5.0782
关键词:
摘要: ✓ The cytotoxic, antiproliferative, and radiosensitizing effects of thymidine (a nucleoside metabolite) were studied using the C6 glioma cell line in vitro. Radiosensitization by a combination 41.8°C hyperthermia was also evaluated. Thymidine concentrations above 100 µg/ml completely inhibited proliferation while to 1000 (for up 24 hours) decreased survival as little 7.4% compared untreated control cells. Radiosensitivity enhanced administration alone (400 × hours before irradiation); sensitization (1 hour ending immediately irradiation) less pronounced. together produced greater radiosensitization than did heat or alone. These data support further investigation neuro-oncology radiosensitizer.
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