作者: Siew Ping Han , Alpha S. Yap
DOI: 10.1007/978-94-007-4186-7_6
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摘要: This chapter discusses the biochemical and functional links between classical cadherin adhesion systems cytoskeleton. Cadherins are best understood to cooperate with actin cytoskeleton, but there is increasing evidence for role of junctional microtubules in regulating biology. Cadherin adhesions cytoskeleton both highly dynamic that undergo continual assembly, turnover remodeling, yet maintain steady state structures necessary intercellular adhesion. requires coordination cadherins cadherin-binding proteins, regulatory organizers microtubule assembly structure, signaling pathways. These components act concert regulate organization response extracellular forces changing cellular contexts, which essential cohesion tissue integrity.