Effectiveness and safety of high dose oxytocin for augmentation of labour in nulliparous women

摘要: augmentation of labour in nulliparous women. Design: An open randomised controlled clinical trial. Setting: Harare Maternity Hospital, Zimbabwe. Subjects: 258 women, with spontaneous onset labour, who required augmentation. Main Outcomes Measures: Duration augmentation, mode delivery, maternal and neonatal complications. Interventions: Women were randomly allocated to either low dose (starting at 4 mlU/minute) or high lOmIU/minute) oxytocin group. Results: Of the women enrolled, 133 randomized 125 starting groups. The groups comparable for gestational age. There was no difference mean cervical dilatation before labour; six cm both (p=0.167). delivery interval shorter group, 218 versus 326 minutes (p< 0.001). fetal outcome terms birthweight, five minute Apgar score, admission unit perinatal death. Conclusion: A infusion is as safe but more effective compared a dose.