作者: David Hickey , Barbara Todd , Mark S. Soloway
DOI: 10.1016/S0022-5347(17)45200-1
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摘要: From June 1982 to February 1985, 53 patients with stage D2 carcinoma of the prostate confirmed by tissue biopsy, elevated prostatic acid phosphatase and a positive bone scan were initiated on androgen deprivation therapy. Before commencement treatment all underwent determination serum testosterone levels at 8 a.m. Of 23 received 200 mcg. buserelin per day, 17 1 mg. diethylstilbestrol 3 times daily, 6 40 megestrol acetate 4 2 leuprolide day 5 bilateral orchiectomy. Evaluation best response in each patient revealed (6 cent) complete (32 partial responses, while 22 (41 remained stable 11 (21 had progression. Pre-treatment ranged from 150 879 ng. dl. The mean level having was 524 +/- 18.04 progression group 279.4 110.1 This difference not statistically significant owing large standard deviation group. However, 15 who pre-treatment more than 500 only (7 None whose less objective tumor regression. Our study suggests that may predict probability satisfactory