Ossabaw Pig Demonstrates Detrusor Fibrosis and Detrusor Underactivity Associated with Oxidative Stress in Metabolic Syndrome.

摘要: Metabolic Syndrome (MetS) has detrimental effects on the bladder, including detrusor underactivity. The progression and mechanism of disease are poorly understood. A swine model for diabetic bladder dysfunction (DBD) was established because pig's human-sized its ability to develop MetS by dietary modification alone. hypothesis this study is that will demonstrate oxidative stress associated with MetS, which contributes both fibrosis underactivity (DU). Ossabaw pigs underwent consisting a hypercaloric, atherogenic diet 10 mo induce were compared group control (lean) pigs. Urodynamic studies performed in groups confirm DU. Thiobarbituric acid reactive substances (TBARS) detected urine used measure activity urinary tract, IL17a detect profibrotic activity. confirmed assessing body weight, blood pressure, glucose tolerance, total cholesterol, triglycerides. exhibited an increase relative levels TBARS IL17a. Bladder pressures at capacity lower group, suggesting Histologic analysis cohort revealed as pigs, had significantly more collagen muscularis layer, but not submucosa or mucosa layer. In conclusion, pig diet-induced results This previously been shown mice rats, never novel better represent human DBD size closely resemble human, resulting valid facilitating further into signaling mechanisms responsible impairment.