Effect of corticosteroid treatment on various serological & bronchoalveolar lavage abnormalities in patients with sarcoidosis.

摘要: Effect of daily oral prednisolone treatment was studied in 29 patients with pulmonary sarcoidosis. Twenty normal control subjects were also studied. Pretreatment absolute lymphocyte counts and proportion lymphocytes peripheral blood significantly lower sarcoidosis as compared to controls. Total cell count the bronchoalveolar lavage (BAL) fluid higher The CD3+ CD4+ BAL Immunoglobulins (IgG, A M) complements (C3, C4 CH50) both fluid. Patients treated (30 mg/day). Repeat studies performed after an interval 4-6 months 20 significant increase decrease occurred treatment. Proportion CD3+, B cells increased decreased Complement immunoglobulin levels revealed a reduction It is concluded that have lymphopaenia lymphocytic alveolitis. They complement immunoglobulins All these abnormalities show improvement