Molecular imaging of biologic characteristics and drug uptake : towards personalized medicine using dose painting
作者： HJWL Aerts
DOI:
关键词:
摘要: One of the innovations in medical care is offering customized treatment. The expectation that these specific treatments will improve survival chances cancer patients. This PhD research studied molecular imaging techniques for this role. findings were CT-PET scans can be used to identify most dangerous areas tumour compensated with a higher dose radiotherapy. In upcoming years, hypothesis tested on basis successful results. was financed by Koningin Wilhelmina Fonds (Dutch Cancer Society).
narcis.nl参考文章(32)
Johan F. Vansteenkiste, Sigrid G. Stroobants, Patrick J. Dupont, Paul R. De Leyn, Erik K. Verbeken, Georges J. Deneffe, Luc A. Mortelmans, Maurits G. Demedts, Prognostic Importance of the Standardized Uptake Value on18F-Fluoro-2-Deoxy-Glucose–Positron Emission Tomography Scan in Non–Small-Cell Lung Cancer: An Analysis of 125 Cases Journal of Clinical Oncology. ,vol. 17, pp. 3201- 3206 ,(1999) , 10.1200/JCO.1999.17.10.3201
Mohamed Hebbar, Agne`s Wacrenier, Christophe Desauw, Olivier Romano, Ste??phane Cattan, Jean-Pierre Triboulet, Francois-Rene?? Pruvot, Lack of usefulness of epidermal growth factor receptor expression determination for cetuximab therapy in patients with colorectal cancer. Anti-Cancer Drugs. ,vol. 17, pp. 855- 857 ,(2006) , 10.1097/01.CAD.0000217425.44584.9F
Jesper G. Eriksen, Torben Steiniche, Jens Overgaard, The influence of epidermal growth factor receptor and tumor differentiation on the response to accelerated radiotherapy of squamous cell carcinomas of the head and neck in the randomized DAHANCA 6 and 7 study Radiotherapy and Oncology. ,vol. 74, pp. 93- 100 ,(2005) , 10.1016/J.RADONC.2004.12.018
Eric P. Visser, Antoon T. Willemsen, Bertjan Arends, Fred J. Verzijlbergen, Josee Zijlstra, Anne M. Paans, Emile F. I. Comans, Jan Pruim, Ronald Boellaard, Wim J. G. Oyen, Corneline J. Hoekstra, Otto S. Hoekstra, The Netherlands protocol for standardisation and quantification of FDG whole body PET studies in multi-centre trials European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 35, pp. 2320- 2333 ,(2008) , 10.1007/S00259-008-0874-2
Lise Bentzen, Susanne Keiding, Michael R. Horsman, Tove Grönroos, Søren B. Hansen, Jens Overgaard, Assessment of Hypoxia in Experimental Mice Tumours by [ 18 F] Fluoromisonidazole PET and pO 2 Electrode Measurements Acta Oncologica. ,vol. 41, pp. 304- 312 ,(2002) , 10.1080/02841860260088863
Christophe Dooms, Angela van Baardwijk, Eric Verbeken, Robert Jan van Suylen, Sigrid Stroobants, Dirk De Ruysscher, Johan Vansteenkiste, Association Between 18F-Fluoro-2-Deoxy-d-Glucose Uptake Values and Tumor Vitality: Prognostic Value of Positron Emission Tomography in Early-Stage Non-small Cell Lung Cancer Journal of Thoracic Oncology. ,vol. 4, pp. 822- 828 ,(2009) , 10.1097/JTO.0B013E3181A97DF7
Marianne Nordsmark, Julie Loncaster, Christina Aquino-Parsons, Shu-Chuan Chou, Val Gebski, Catharine West, Jacob C. Lindegaard, Hanne Havsteen, Susan E. Davidson, Robin Hunter, James A. Raleigh, Jens Overgaard, The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study. Radiotherapy and Oncology. ,vol. 80, pp. 123- 131 ,(2006) , 10.1016/J.RADONC.2006.07.010
Anthony Fyles, Michael Milosevic, Melania Pintilie, Ami Syed, Wilf Levin, Lee Manchul, Richard P. Hill, Long-term performance of interstial fluid pressure and hypoxia as prognostic factors in cervix cancer. Radiotherapy and Oncology. ,vol. 80, pp. 132- 137 ,(2006) , 10.1016/J.RADONC.2006.07.014
Marianne Nordsmark, Jens Overgaard, A confirmatory prognostic study on oxygenation status and loco-regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy. Radiotherapy and Oncology. ,vol. 57, pp. 39- 43 ,(2000) , 10.1016/S0167-8140(00)00223-1
Daniela Thorwarth, Susanne-Martina Eschmann, Frank Paulsen, Markus Alber, Hypoxia dose painting by numbers: a planning study. International Journal of Radiation Oncology Biology Physics. ,vol. 68, pp. 291- 300 ,(2007) , 10.1016/J.IJROBP.2006.11.061