Ubiquitin signalling in DNA replication and repair
作者： Helle D. Ulrich , Helen Walden
DOI: 10.1038/NRM2921
关键词:
摘要: Post-translational modification by ubiquitin is best known for its role in targeting substrates regulated degradation. However, non-proteolytic functions of the system, often involving either monoubiquitylation or polyubiquitylation through Lys63-linked chains, have emerged various cell signalling pathways. These two forms signal contribute to three different pathways related maintenance genome integrity that are responsible processing DNA double-strand breaks, repair interstrand cross links and bypass lesions during replication.
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