Airway anastomotic dehiscence associated with use of sirolimus immediately after lung transplantation.

摘要: Goal. The goal of this study was to assess the efficacy sirolimus in lung-transplant recipients. Methods. designed as a single center, consecutive case recipients treated with sirolimus, tacrolimus, and prednisone. All subjects also received an HMG-CoA reductase inhibitor, prophylaxis for cytomegalovirus Pneumocystis carinii. Results. A total 15 were enrolled study. Within 6 months, significant airway complications occurred four subjects, three whom died. At that point, investigators terminated enrollment population compared retrospectively group 83 lung cyclosporine (n=64) or tacrolimus (n=19), mycophenolate mofetil, This confirmed increased incidence dehiscence reduced survival sirolimus-treated patients. Sirolimus-treated patients had low acute rejection. No differences noted bacterial fungal bronchopulmonary infections. Conclusions. We observed unexpectedly high postoperative combination prednisone, inhibitor. Further studies will be needed determine safety using after complete healing has occurred.