Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists

摘要: Serotonergic transmission has been suggested to modulate the effects of cocaine. However, specific receptors underlying this phenomenon have not identified. To evaluate role 5-HT1B receptor in mediating actions cocaine, we used two model systems: knockout (KO) mice lacking and an acute treatment with 5-HT1B/1D antagonist GR127935. GR127935 attenuated ability cocaine stimulate locomotion induce c-fos expression striatum. had no apparent effect on rewarding or sensitizing In contrast, as demonstrated previously, KO showed a heightened locomotor response well increased propensity self-administer Thus, pharmacological blockade decreases some while constitutive genetic same opposite effects. These results suggest that compensatory changes taken place during development mice, which may rendered these more vulnerable The should therefore be considered vulnerability drug abuse rather than classic tool.