Echinochrome A Improves Exercise Capacity during Short-Term Endurance Training in Rats

摘要: Echinochrome A (Echi A) improves mitochondrial function in the heart; however, its effects on skeletal muscle are still unclear. We hypothesized that Echi administration during short-term exercise may improve capacity. Twenty-four male Sprague-Dawley rats were randomly divided into following groups: control group (CG), A-treated (EG), aerobic (AG), and treated with (AEG) (n = 6 per group). was administered intra-peritoneally (0.1 mg/kg of 300 µL phosphate-buffered saline) daily 30 min before each training. The AG AEG groups performed treadmill running (20 m/min, 60 min/day) five days/week for two weeks. capacity significantly higher compared to other groups. Interestingly, increased more effectively group. body weight EG tended be slightly lower than There no significant changes plasma lipids among However, gastrocnemius mitochondria content greater These findings show after endurance training enhances capacity, which associated an increase content.