A nomogram for predicting locoregional recurrence in primary breast cancer patients who received breast-conserving surgery after neoadjuvant chemotherapy.
作者： Naoko Matsuda , Naoki Hayashi , Sachiko Ohde , Hiroshi Yagata , Yuka Kajiura
DOI: 10.1002/JSO.23586
关键词:
摘要: Background We sought to develop and validate a predictive model of locoregional recurrence (LRR) in patients who underwent breast-conserving therapy (BCT) after neoadjuvant chemotherapy (NAC). Patients methods The clinicopathological characteristics 520 consecutive primary breast cancer with residual tumor BCT NAC between 2001 2008 were evaluated. Predictive variables LRR determined using multivariate Cox proportional hazards model. The was validated for discrimination calibration by bootstrap re-sampling. Results At median follow-up period 51 months, 64 (12%) had developed LRR. Clinical stage T3 or T4, lymphovascular invasion, nuclear grade >3, ≥4 positive lymph nodes metastasis positively correlated nomogram predicting these four-clinicopathologic demonstrated high concordance. Patients score 0–1 derived the prediction significantly low rate compared 2 higher (P < 0.001). Conclusions This may be useful predict reproducibility. This is conduct study-identifying need an additional treatment standard adjuvant because probability J. Surg. Oncol. 2014 109:764–769. © Wiley Periodicals, Inc.
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