Conditional Depletion of Hippocampal Brain-Derived Neurotrophic Factor Exacerbates Neuropathology in a Mouse Model of Alzheimer’s Disease:

摘要: Damage occurring to noradrenergic neurons in the locus coeruleus (LC) contributes evolution of neuroinflammation and neurodegeneration a variety conditions diseases. One cause LC damage may be loss neurotrophic support from target regions. We tested this hypothesis by conditional unilateral knockout brain-derived factor (BDNF) adult mice. To evaluate consequences BDNF context neurodegeneration, mice harbored familial mutations for human amyloid precursor protein presenilin-1. In these mice, depletion reduced tyrosine hydroxylase staining, marker neurons, rostral LC. also innervation hippocampus, frontal cortex, molecular layer cerebellum, assessed staining dopamine beta hydroxylase. led an increase cortical plaque numbers size but was without effect on striatum, site with minimal ...