An increased NM23H1 copy number may be a poor prognostic factor independent of LOH on 1p in neuroblastomas

摘要: In a study of 154 neuroblastomas, loss heterozygosity (LOH) was observed on 1p (13%, 19/143), 11q (19%, 11/59), 14q (15%, 15/97), 17p (5%, 5/105) and 17q (17%, 9/52). We also found an increase in NM23H1 copy number 14% (13/95) neuroblastomas. All except one tumour with increased stained positive anti-NM23H1 monoclonal antibody. Event-free survival (EFS) significantly shorter 19 patients LOH than 128 without (41% vs 77% 4 year EFS, P=0.0093), 13 numbers 82 normal the gene (61% 84% P=0.0103). 11q, or did not affect EFS. Most tumours 1p, MYCN amplification occurred aged 12 months more, those advanced stage disease, who showed near diploidy pseudodiploidy. However, only 1 numbers, four copies other such tumour. These findings suggest that may be predictor for poor prognosis, independent probably amplification.