Allelic and somatic variations in the endogenous opioid system of humans
作者： P Mayer , V Höllt
DOI: 10.1016/S0163-7258(01)00154-1
关键词:
摘要: People with a genetic predisposition for substance abuse have defects in genes the opioid peptides and receptors. A high number of polymorphisms been detected mu-opioid receptor, some which result pharmacological alterations. The peptide proopiomelanocortin proved extraordinarily rich mutations that often lead to severe phenotypical consequences. Prodynorphin displays polymorphic regulation transcription. Variants mu- delta-opioid receptor showed positive associations opiate and/or alcohol addiction studies. However, these were weak, indicating small contribution system disorders.
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