Role of Senescent Renal Cells in Pathophysiology of Diabetic Kidney Disease.

摘要: Diabetic kidney disease (DKD) is the leading cause of failure in USA, representing ~ 44% all cases failure. Advancements both glucose management and inhibitors renin-angiotensin system have significantly improved prognosis for individuals with DKD, yet DKD continues to affect 30–40% people type 2 diabetes still a major predictor mortality this population. Thus, new interventions are required address significant health burden. One potential target intervention cellular senescence. Senescence permanently arrests cell division response genotoxic, oncogenic, or metabolic stresses—coupled secretion inflammatory cytokines, chemokines, growth factors, proteases, other molecules that can potent local systemic effects. This senescence-associated secretory phenotype (SASP) explains how relatively small number senescent cells promote pathology, growing degenerative conditions been found be caused aggravated by cells. Many SASP factors also associated loss function. Targeted elimination prevents development several pathologies. Since appear proximal tubules podocytes patients they an appealing these disorders. Here, we review current literature linking senescence speculate on likely routes clinical setting.