ADC, D, f dataset calculated through the simplified IVIM model, with MGMT promoter methylation, age, and ECOG, in 38 patients with wildtype IDH glioblastoma.

摘要: Patients undergoing standard chemoradiation post-resection had MRIs at radiation planning and fractions 10 20 of chemoradiation. were 1.5T 3D T2-FLAIR, pre- post-contrast T1-weighted (T1) echo planar DWI with three b-values (0, 500, 1000s/mm2) acquired. T2-FLAIR was coregistered to T1C images. Non-overlapping T1 contrast-enhancing (T1C) nonenhancing hyperintense regions segmented, necrotic/cystic regions, the surgical cavity, large vessels excluded. The simplified IVIM model used calculate voxelwise diffusion coefficient (D) perfusion fraction (f) maps; ADC calculated using natural logarithm b = 1000 over b = 0 segmentations brought into this space, medians calculated. MGMT promoter methylation status (MGMTPMS), age diagnosis, Eastern Cooperative Oncology Group (ECOG) performance extracted from electronic medical records. data presented, analyzed, described in article, "Intravoxel incoherent motion (IVIM) modeling MRI during predicts therapeutic response IDH wildtype Glioblastoma", published Radiotherapy [1].