Thyroid autoimmunity in patients on long term therapy with leukocyte-derived interferon.
作者： PIA BURMAN , THOMAS H. TÖTTERMAN , K. ÖBERG , F. ANDERS KARLSSON
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摘要: Among 49 patients with carcinoid tumors given long term therapy (mean, 8 months; range, 3-36) human leukocyte-derived interferon-a (huLe-IFNa), hypothyroidism occurred in 5 andthyrotoxicosis 2. Antibodies against thyroid microsomal antigen and/or thyroglobulin were found 13 patients. In 7 of these, 3 whom developed hypothyroidism, the antibodies appeared aferthe start therapy. During treatment, an increase proportions circulating activated surface HLA-DR-positive T-helper and T-suppressor cells after 3-4 days, remained elevated at 6 months. Incubation T normal individuals vitro withthe huLe-IFNa preparation induced a rise cells. This effect was mimicked by recombinant IFN7 (r-IFN7), but not r-IFNa. Further, employed HLA-DR expression on tissue culture as did T-IFNY, r-IFNa, suggesting presence bioactive hu...
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R Jansson, A Karlsson, U Forsum, Intrathyroidal HLA-DR expression and T lymphocyte phenotypes in Graves’ thyrotoxicosis, Hashimoto’s thyroiditis and nodular colloid goitre Clinical and Experimental Immunology. ,vol. 58, pp. 264- 272 ,(1984)
W L Farrar, H M Johnson, J J Farrar, Regulation of the production of immune interferon and cytotoxic T lymphocytes by interleukin 2. Journal of Immunology. ,vol. 126, pp. 1120- 1125 ,(1981)
T Hanafusa, L Chiovato, Deborah Doniach, R Pujol-Borrell, R.C.G Russell, G.F Bottazzo, Aberrant expression of HLA-DR antigen on thyrocytes in Graves' disease: relevance for autoimmunity The Lancet. ,vol. 322, pp. 1111- 1115 ,(1983) , 10.1016/S0140-6736(83)90628-1
F. Rosa, M. Fellous, The effect of gamma-interferon on MHC antigens Immunology Today. ,vol. 5, pp. 261- 262 ,(1984) , 10.1016/0167-5699(84)90135-X
Marco Londei, Jonathan R. Lamb, Gian Franco Bottazzo, Marc Feldmann, Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells Nature. ,vol. 312, pp. 639- 641 ,(1984) , 10.1038/312639A0
T. Bjøro, P. I. Gaarder, E. B. Smeland, L. Kornstad, Thyroid antibodies in blood donors: prevalence and clinical significance European Journal of Endocrinology. ,vol. 105, pp. 324- 329 ,(1984) , 10.1530/ACTA.0.1050324
J. H. Lazarus, M. L. Burr, A. M. McGregor, A. P. Weetman, M. Ludgate, J. S. Woodhead, R. Hall, The prevalence and progression of autoimmune thyroid disease in the elderly. European Journal of Endocrinology. ,vol. 106, pp. 199- 202 ,(1984) , 10.1530/ACTA.0.1060199
GianFranco Bottazzo, Toshiaki Hanafusa, Ricardo Pujol-Borrell, Marc Feldmann, ROLE OF ABERRANT HLA-DR EXPRESSION AND ANTIGEN PRESENTATION IN INDUCTION OF ENDOCRINE AUTOIMMUNITY The Lancet. ,vol. 2, pp. 1115- 1119 ,(1983) , 10.1016/S0140-6736(83)90629-3
Richard A. Jackson, Mary A. Morris, Barton F. Haynes, George S. Eisenbarth, Increased circulating Ia-antigen-bearing T cells in type I diabetes mellitus. The New England Journal of Medicine. ,vol. 306, pp. 785- 788 ,(1982) , 10.1056/NEJM198204013061305
P. Burman, F.A. Karlsson, K. Öberg, G. Alm, Mauri Orava, Reijo Vihko, AUTOIMMUNE THYROID DISEASE IN INTERFERON-TREATED PATIENTS The Lancet. ,vol. 326, pp. 100- 101 ,(1985) , 10.1016/S0140-6736(85)90203-X