Method for predicting interaction between nucleotides in nucleic acid structure
作者： Jian Yiren , Wang Xiaonan , Zeng Chen , Zhao Yunjie , Jia Ya
DOI:
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摘要: The invention discloses a method for predicting interaction between nucleotides in nucleic acid structure. According to the method, sequence coevolution relationship of homologous sequences is calculated by utilizing direct coupling analysis method; and characteristics three-dimensional structure are analyzed machine learning model, then nucleotide-nucleotide predicted combining characteristics. Results show that prediction result interactionranking first 100, precision improved 4%-15%, compared with traditional method. molecule three-level improved, important help provided modeling functional mechanism research.
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