Hypodiploidy is a major prognostic factor in multiple myeloma
作者： Nicole Véronique Smadja , Christian Bastard , Christophe Brigaudeau , Dominique Leroux , Christophe Fruchart
关键词:
摘要: Conventional karyotypes performed before any treatment in 208 patients with multiple myeloma were reviewed by the Groupe Francais de Cytogenetique Hematologique. A total of 138 displayed complex chromosomal abnormalities (CCAs). According to chromosome number pattern, a first group 75 had hyperdiploid karyotype. second 63 referred as hypodiploid either pseudodiploid, hypodiploid, or near-tetraploid karyotypes. Of 159 treated available for survival analysis, 116 an abnormal The comparison overall (OS) between and showed highly significant difference (median OS 33.8 vs 12.6 months, respectively, P
ashpublications.org
bloodjournal.org参考文章(55)
J. Epstein, J. R. Sawyer, R. G. Hoover, D. D. Dao, B. Barlogie, G. Tricot, Deletion of the retinoblastoma gene in multiple myeloma. Leukemia. ,vol. 8, pp. 1280- 1284 ,(1994)
M Taniwaki, K Nishida, T Takashima, H Nakagawa, H Fujii, T Tamaki, C Shimazaki, S Horiike, S Misawa, T Abe, Nonrandom chromosomal rearrangements of 14q32.3 and 19p13.3 and preferential deletion of 1p in 21 patients with multiple myeloma and plasma cell leukemia. Blood. ,vol. 84, pp. 2283- 2290 ,(1994) , 10.1182/BLOOD.V84.7.2283.2283
JL Lai, M Zandecki, JY Mary, F Bernardi, V Izydorczyk, M Flactif, P Morel, JP Jouet, F Bauters, T Facon, Improved cytogenetics in multiple myeloma: a study of 151 patients including 117 patients at diagnosis Blood. ,vol. 85, pp. 2490- 2497 ,(1995) , 10.1182/BLOOD.V85.9.2490.BLOODJOURNAL8592490
J.A. Pérez-Simón, R. Garcı́a-Sanz, M.D. Tabernero, J. Almeida, M. González, J. Fernández-Calvo, M.J. Moro, J.M. Hernández, J.F. San Miguel, A. Orfão, Prognostic Value of Numerical Chromosome Aberrations in Multiple Myeloma: A FISH Analysis of 15 Different Chromosomes Blood. ,vol. 91, pp. 3366- 3371 ,(1998) , 10.1182/BLOOD.V91.9.3366
J Gould, R Alexanian, A Goodacre, S Pathak, B Hecht, B Barlogie, Plasma Cell Karyotype in Multiple Myeloma Blood. ,vol. 71, pp. 453- 456 ,(1988) , 10.1182/BLOOD.V71.2.453.BLOODJOURNAL712453
J Latreille, B Barlogie, G Dosik, DA Johnston, B Drewinko, R Alexanian, Cellular DNA content as a marker of human multiple myeloma. Blood. ,vol. 55, pp. 403- 408 ,(1980) , 10.1182/BLOOD.V55.3.403.403
Dolores Tabernero, Jesus F San Miguel, M Garcia-Sanz, Luisa Najera, María García-Isidoro, Jose A Perez-Simon, Marcos Gonzalez, Joop Wiegant, Anton K Raap, Alberto Orfão, Incidence of chromosome numerical changes in multiple myeloma: fluorescence in situ hybridization analysis using 15 chromosome-specific probes. American Journal of Pathology. ,vol. 149, pp. 153- 161 ,(1996)
B Barlogie, R Alexanian, D Dixon, L Smith, L Smallwood, K Delasalle, Prognostic implications of tumor cell DNA and RNA content in multiple myeloma Blood. ,vol. 66, pp. 338- 341 ,(1985) , 10.1182/BLOOD.V66.2.338.338
GW Dewald, RA Kyle, GA Hicks, PR Greipp, The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis Blood. ,vol. 66, pp. 380- 390 ,(1985) , 10.1182/BLOOD.V66.2.380.380
Niklas Zojer, Robert Königsberg, Jutta Ackermann, Elke Fritz, Susanne Dallinger, Elisabeth Krömer, Hannes Kaufmann, Lucia Riedl, Heinz Gisslinger, Susanne Schreiber, Renate Heinz, Heinz Ludwig, Heinz Huber, Johannes Drach, Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization. Blood. ,vol. 95, pp. 1925- 1930 ,(2000) , 10.1182/BLOOD.V95.6.1925