Prognostic Value of MicroRNAs in Stage II Colorectal Cancer Patients: A Systematic Review and Meta-Analysis.

摘要: We performed a systematic review and meta-analysis to identify underline multiple microRNAs (miRNAs) as biomarkers of disease prognosis in stage II colorectal cancer (CRC) patients. This study was conducted according Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines. The required articles were collected from online bibliographic databases January 2011 November 2019 with permutation keywords. Quantitative data synthesis based on pooled observe analyse the outcome measures effect estimates by using random model. subgroup analysis demographic characteristics available data. Eighteen included this study, 16 which incorporated examine CRC up- downregulated miRNA expressions. hazard ratio (HR) death patients 1.90 (95% confidence interval 1.63–2.211), significant p value. A or expression individually any deregulated also associated worse prognosis. parameters such age, gender, III combined patients’ survival repetitive miRNAs (miR21, miR215, miR143-5p, miR106a miR145) individually. MicroRNAs play role determining patients, upregulation miR21, miR143-5p miR106a, particular, portending These could be considered further evaluation guide decision administer adjuvant chemotherapy.