as-PSOCT: Volumetric microscopic imaging of human brain architecture and connectivity
作者： Hui Wang , Caroline Magnain , Ruopeng Wang , Jay Dubb , Ani Varjabedian
DOI: 10.1016/J.NEUROIMAGE.2017.10.012
关键词:
摘要: Polarization sensitive optical coherence tomography (PSOCT) with serial sectioning has enabled the investigation of 3D structures in mouse and human brain tissue samples. By using intrinsic properties back-scattering birefringence, PSOCT reliably images cytoarchitecture, myeloarchitecture fiber orientations. In this study, we developed a fully automatic polarization (as-PSOCT) system to enable volumetric reconstruction samples unprecedented sample size resolution. The 3.5 μm in-plane resolution 50 μm through-plane voxel allow inspection cortical layers that are single-cell width, as well small crossing fibers. We show abilities as-PSOCT quantifying layer thicknesses cerebellar cortex creating microscopic tractography intricate networks subcortical nuclei internal capsule regions, all based on reconstructions. provides viable tool for studying quantitative cytoarchitecture mapping connectivity brain.
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