Effects of Simultaneous Treatment with Growth Factors on DNA Synthesis, MAPK Activity, and G1 Cyclins in Rat Hepatocytes
作者： Akio Ido , Akihiro Moriuchi , Shuichi Hirono , Hirohito Tsubouchi
DOI: 10.1007/978-4-431-67887-8_7
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摘要: Several growth factors act in concert during liver regeneration vivo. Once hepatic injury occurs, is stimulated by hepatocyte factor (HGF), transforming (TGF)-α, and heparin-binding epidermal factor-like (HB-EGF), whereas TGF-s1 terminates regeneration. Treatment with a combination of HGF (EGF), comparison that either or EGF, was found to additively stimulate mitogen-activated protein kinase (MAPK) activity cyclin D1 expression additively, resulting additive stimulation DNA synthesis. In contrast, treatment completely inhibited synthesis through marked decrease E expression, although factor-induced MAPK were not affected TGF-s1. These results indicate potent mitogens such as HGF, TGF-α, HB-EGF can cooperatively induce the enhancement ofliver an increase Ras/MAPK followed suppresses signals between E, inhibition
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sci-hub.st 参考文章(26)
Pascal Loyer, Sandrine Cariou, Denise Glaise, Marc Bilodeau, Georges Baffet, Christiane Guguen-Guillouzo, Growth factor dependence of progression through G1 and S phases of adult rat hepatocytes in vitro. Evidence of a mitogen restriction point in mid-late G1. Journal of Biological Chemistry. ,vol. 271, pp. 11484- 11492 ,(1996) , 10.1074/JBC.271.19.11484
L.E. Gentry, A. Lawton, Characterization of site-specific antibodies to the erbB gene product and EGF receptor: Inhibition of tyrosine kinase activity Virology. ,vol. 152, pp. 421- 431 ,(1986) , 10.1016/0042-6822(86)90144-3
E. Gohda, H. Tsubouchi, H. Nakayama, S. Hirono, K. Takahashi, M. Koura, S. Hashimoto, Y. Daikuhara, Human hepatocyte growth factor in plasma from patients with fulminant hepatic failure. Experimental Cell Research. ,vol. 166, pp. 139- 150 ,(1986) , 10.1016/0014-4827(86)90514-8
N. Ito, S. Kawata, S. Tamura, S. Kiso, H. Tsushima, D. Damm, J.A. Abraham, S. Higashiyama, N. Taniguchi, Y. Matsuzawa, Heparin-Binding EGF-like Growth-Factor Is a Potent Mitogen for Rat Hepatocytes Biochemical and Biophysical Research Communications. ,vol. 198, pp. 25- 31 ,(1994) , 10.1006/BBRC.1994.1004
E Gohda, H Tsubouchi, H Nakayama, S Hirono, O Sakiyama, K Takahashi, H Miyazaki, S Hashimoto, Y Daikuhara, Purification and partial characterization of hepatocyte growth factor from plasma of a patient with fulminant hepatic failure. Journal of Clinical Investigation. ,vol. 81, pp. 414- 419 ,(1988) , 10.1172/JCI113334
Susan Kennedy, Steve Rettinger, M. Wayne Flye, Katherine Parker Ponder, Experiments in transgenic mice show that hepatocytes are the source for postnatal liver growth and do not stream Hepatology. ,vol. 22, pp. 160- 168 ,(1995) , 10.1002/HEP.1840220126
J. E. Mead, N. Fausto, Transforming growth factor alpha may be a physiological regulator of liver regeneration by means of an autocrine mechanism. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 1558- 1562 ,(1989) , 10.1073/PNAS.86.5.1558
Isabelle Royal, Tanya M. Fournier, Morag Park, Differential requirement of Grb2 and PI3-kinase in HGF/SF-induced cell motility and tubulogenesis Journal of Cellular Physiology. ,vol. 173, pp. 196- 201 ,(1997) , 10.1002/(SICI)1097-4652(199711)173:2<196::AID-JCP20>3.0.CO;2-D
J. A. Rhim, E. P. Sandgren, R. D. Palmiter, R. L. Brinster, Complete reconstitution of mouse liver with xenogeneic hepatocytes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 4942- 4946 ,(1995) , 10.1073/PNAS.92.11.4942
C J Sherr, J M Roberts, Inhibitors of mammalian G1 cyclin-dependent kinases. Genes & Development. ,vol. 9, pp. 1149- 1163 ,(1995) , 10.1101/GAD.9.10.1149