Synthesis of chiral α- substituted β-hydroxy acid derivatives on solid support
作者： Ashok V Purandare , Sesha Natarajan
DOI: 10.1016/S0040-4039(97)10378-1
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摘要: Abstract Enantioselective aldol condensation using solid supported chiral auxiliary was used for the synthesis of α-substituted-β-hydroxy acid and ester. The phase proceeded with high degree enatioselectivity, as is observed in solution chemistry.
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sci-hub.se 参考文章(5)
D. A. Evans, J. Bartroli, T. L. Shih, Enantioselective aldol condensations. 2. Erythro-selective chiral aldol condensations via boron enolates Journal of the American Chemical Society. ,vol. 103, pp. 2127- 2129 ,(1981) , 10.1021/JA00398A058
Lutz S. Richter, Thomas R. Gadek, A surprising observation about Mitsunobu reactions in solid phase synthesis Tetrahedron Letters. ,vol. 35, pp. 4705- 4706 ,(1994) , 10.1016/S0040-4039(00)76946-2
Steven M. Allin, Stephen J. Shuttleworth, THE PREPARATION AND FIRST APPLICATION OF A POLYMER-SUPPORTED EVANS OXAZOLIDINONE Tetrahedron Letters. ,vol. 37, pp. 8023- 8026 ,(1996) , 10.1016/0040-4039(96)01815-1
Mark J. Kurth, Lisa A. Ahlberg Randall, Chixu Chen, Christian Melander, R. Bryan Miller, Kelly McAlister, Gary Reitz, Raphael Kang, Tetsuo Nakatsu, Carter Green, Library-Based Lead Compound Discovery: Antioxidants by an Analogous Synthesis/Deconvolutive Assay Strategy Journal of Organic Chemistry. ,vol. 59, pp. 5862- 5864 ,(1994) , 10.1021/JO00099A008
Guo-Jie Ho, David J. Mathre, LITHIUM-INITIATED IMIDE FORMATION. A SIMPLE METHOD FOR N-ACYLATION OF 2-OXAZOLIDINONES AND BORNANE-2,10-SULTAM Journal of Organic Chemistry. ,vol. 60, pp. 2271- 2273 ,(1995) , 10.1021/JO00112A060