Histopathological classification of antineutrophil cytoplasmic antibody-associated glomerulonephritis: an update.

摘要: Purpose of review This discusses the findings studies validating histopathological classification antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis, which was devised in 2010 by an international working group pathologists and nephrologists collaboration with European Vasculitis Society. Recent So far, eight have validated ANCA-associated glomerulonephritis. The came from Japan, China, Australia, United States, Netherlands, Turkey. These validation confirmed that glomerulonephritis is predictive value for renal outcome. especially case patients either a focal or sclerotic-class biopsy, whereas crescentic mixed classes showed different results studies. differences could be due to patient populations therapy, inter-rater reliability lack inclusion tubulointerstitial lesions classification. Therapy known influence outcome, but retrospective design to-date performed studies, this parameter not fully accounted these Inter-rater among three histopathologists investigated one study moderate. Summary predicts outcome during follow-up, biopsy. A large currently being performed. Video abstract http://links.lww.com/CONH/A6.