Activation of AMP-Activated Protein Kinase Contributes to Doxorubicin-Induced Cell Death and Apoptosis in Cultured Myocardial H9c2 Cells
作者： Min-Bin Chen , Xiao-Yang Wu , Jin-Hua Gu , Qing-Tao Guo , Wen-Xiang Shen
DOI: 10.1007/S12013-011-9153-0
关键词:
摘要: Despite its potent antitumor effect, clinical use of Doxorubicin is limited because serious side effects including myocardial toxicity. Understanding the cellular mechanism involved in this process a better manner beneficial for optimizing treatment. In current study, authors focus on AMP-activated protein kinase (AMPK) said process. discovered first time that induces AMPK activation cultured rat embryonic ventricular H9c2 cells. Reactive oxygen species (ROS)-dependent LKB1 serves as upstream signal by Doxorubicin. Evidence support contributing to Doxorubicin-induced cell death/apoptosis—probably modulating multiple downstream targets, regulating JNK, p53, and inhibiting mTORC1—is provided article.
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sci-hub.se 参考文章(59)
James H. Doroshow, Effect of Anthracycline Antibiotics on Oxygen Radical Formation in Rat Heart Cancer Research. ,vol. 43, pp. 460- 472 ,(1983)
Kazuhito Yamamoto, Hidenori Ichijo, Stanley J. Korsmeyer, BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M Molecular and Cellular Biology. ,vol. 19, pp. 8469- 8478 ,(1999) , 10.1128/MCB.19.12.8469
M Garcia-Gil, R Pesi, S Perna, S Allegrini, M Giannecchini, M Camici, M.G Tozzi, 5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells. Neuroscience. ,vol. 117, pp. 811- 820 ,(2003) , 10.1016/S0306-4522(02)00836-9
Marcel Verheij, Ron Bose, Xin Hua Lin, Bei Yao, W. David Jarvis, Steven Grant, Michael J. Birrer, Eva Szabo, Leonard I. Zon, John M. Kyriakis, Adriana Haimovitz-Friedman, Zvi Fuks, Richard N. Kolesnick, Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature. ,vol. 380, pp. 75- 79 ,(1996) , 10.1038/380075A0
Jun-Feng Zhang, Jia-Jun Liu, Min-Qiang Lu, Chang-Jie Cai, Yang Yang, Hua Li, Chi Xu, Gui-Hua Chen, None, Rapamycin inhibits cell growth by induction of apoptosis on hepatocellular carcinoma cells in vitro. Transplant Immunology. ,vol. 17, pp. 162- 168 ,(2007) , 10.1016/J.TRIM.2006.12.003
Surender Kharbanda, Pramod Pandey, Ruibao Ren, Bruce Mayer, Leonard Zon, Donald Kufe, None, c-Abl Activation Regulates Induction of the SEK1/Stress-activated Protein Kinase Pathway in the Cellular Response to 1-β-D-Arabinofuranosylcytosine Journal of Biological Chemistry. ,vol. 270, pp. 30278- 30281 ,(1995) , 10.1074/JBC.270.51.30278
Yong Yang, Yang Hu, Hong-Yan Gu, Na Lu, Wei Liu, Qi Qi, Li Zhao, Xiao-Tang Wang, Qi-Dong You, Qing-Long Guo, Oroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells. Journal of Pharmacy and Pharmacology. ,vol. 60, pp. 1459- 1463 ,(2008) , 10.1211/JPP/60.11.0006
Eugene A. Konorev, M.Claire Kennedy, B. Kalyanaraman, Cell-Permeable Superoxide Dismutase and Glutathione Peroxidase Mimetics Afford Superior Protection against Doxorubicin-Induced Cardiotoxicity: The Role of Reactive Oxygen and Nitrogen Intermediates Archives of Biochemistry and Biophysics. ,vol. 368, pp. 421- 428 ,(1999) , 10.1006/ABBI.1999.1337
Kesavan Shan, A Michael Lincoff, James B Young, Anthracycline-Induced Cardiotoxicity Annals of Internal Medicine. ,vol. 125, pp. 47- 58 ,(1996) , 10.7326/0003-4819-125-1-199607010-00008
Ann M. Bode, Zigang Dong, Post-translational modification of p53 in tumorigenesis Nature Reviews Cancer. ,vol. 4, pp. 793- 805 ,(2004) , 10.1038/NRC1455