ENZYMATIC ISOTOPIC ASSAY FOR AND PRESENCE OF ?-PHENYLETHYLAMINE IN BRAIN
作者： J. M. Saavedra
DOI: 10.1111/J.1471-4159.1974.TB11581.X
关键词:
摘要: — An enzymatic isotopic assay for the measurement of β-phenylethylamine in brain, with a sensitivity 100-200 pg, has been developed. With this assay, endogenous content (1.5 ng/g) rat brain determined. Phenylalanine administration increases levels amine; inhibition monoamine oxidase causes 40-fold increase β-phenylethylamine. After combined treatment inhibitor and phenylalanine, to about 400-fold. This can be blocked by central decarboxylase NSD-1055. p-Chlorophenylalanine also β-phenylethylamipe concentration effect is potentiated simultaneous phenylalanine.
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